Constraint Based Modeling

Becker, Scott; et al.Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox.Department of Bioengineering, University of California San Diego.Nature Protocols Vol.2 No.3. March 2007.

  • Briefly describes constraint based modeling and give the principles behind it
  • Describes the functions of the COBRA toolbox and it explains the output of the program

Price, Nathan; et al. Genome-Scale Models of Microbial Cells: Evaluating the Consequences of Constraints.Department of Bioengineering, University of California San Diego. Nature Reviews. Vol.2. November 2004.

  • Describes the constraints one must take into account when creating genome scale models
  • Explains each constraint in detail