Team:NTU-Singapore/Notebook/Brainstorming

From 2009.igem.org

Brainstorming Ideas


Health & medicine

  • Create an insulin delivery system which response to low glucose level or time controlled release


  • Vitamin synthesis?


  • Hinder carcinogenics
    • Maslinic acid (olive skin)-tritrepenoid compound
    • Can we study anti-tumoral and apoptotic effect of this compound?
    • E coli to interfere in the carcinogenic pathways
    • Mimic the maslinic effect to the carcinogenic cells?
    • Surface markers?


  •  Trap parasites in host cells by disabling the protease
    • Can we remove the trap parasites?
    • Terminate parasites?


  • Genetic modified bacteria that have anticoagulant properties.


  • Eczema relief


  • Bacteria to treat gangrene
    • To eat up dead tissues
    • Bacteria to deliver growth factors


  • Collagen producing bacteria


  • Bacteria that absorbs cholesterol


  • Constipation pill


  • Synthesis specific growth factors


  • Bacteria that produce PDGF


  • Using bacteria to breakdown blockage in blood vessels


  • Malaria vaccine
    •  Forcibly expresses a certain gene and create a vaccine against it
    • Proof of concept


  • Cancer treatment - colon cancer(CA marker)
    • Fusion protein to signal the expression of perforin (e coli as NKC)


  • Streptococcus vaccine


  • p-Falciparum gene expression stabilization for malaria


  • Intestinal vaccine delivery


  • Bacteria to target the larvae


  • To separate Tamoxifen (possibly a chiral drug) by uptake the drugs into modified E Coli and bind it to the receptor inside the bacteria.


Biosensor

  • Biosensor that sense the present of allergen and release drugs to prevent allergenic response


  • Mimic allergy response-to determine allergen?


  •  Fingerprint detection


  •  Can cells response to magnetic fields?
    • Bird GPS ??
    • Magnetic field biosensor


  •  Biosensor to detect cancer


Environmental

  • E coli to detect toxins in food and flu strain in animals.


  • Biomask
    •  For absorption


  • Create a water purifying system that recognize and trap toxic
    • to uptake salt and others- sea water purification


  • Bacteria producing water for the use of photosynthesis so that plants can grow well in dry area
    • Is it possible to construct water using certain metabolism pathway?


Signalling

  • Multi-color display according to inputs
    • to improve signal inputs
  • DNA methylation as memory storage
  • suffocate the cells
  • baccine
  • To construct guiding E Coli that guide pathogenic bacteria to a region of toxin/UV light.


Application

  • bacterial barometer
  • fill up crack
  • dust repel
  • microscopic spring-using spirobac
  • To construct a Sound sensing bacteria


Modeling

  • modeling the trend of evolution of flu viruses


Bioproduction

  • Methanol in E-coli





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