Team:Aberdeen Scotland

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== Microbial two-component glue to engineer self-healing pipes;  The Pico-Plumber ==
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Layperson Summary:
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This synthetic biology project will engineer a bacterium from the human gut, Escherichia coli, to detect and fix leaking pipes. Engineered E. coli will detect leaks by homing in on a chemical signal released at the leak site. As the bacteria migrate towards the leak, they will synthesise two proteins, one on the outside of the cell, the other inside, which represent the two components of a biological, protein glue. The adhesive is only activated when the two components mix. The E. coli cells will be engineered to burst at the leak site, mixing the two glue components and creating a sticky protein plug to repair the pipe. 
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== Microbial two-component glue to engineer self-healing pipes;  The Pico-Plumber ==
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Layperson Summary:
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This synthetic biology project will engineer a bacterium from the human gut, ''Escherichia coli'', to detect and fix leaking pipes. Engineered ''E. coli'' will detect leaks by homing in on a chemical signal released at the leak site. As the bacteria migrate towards the leak, they will synthesise two proteins, one on the outside of the cell, the other inside, which represent the two components of a biological, protein glue. The adhesive is only activated when the two components mix. The ''E. coli'' cells will be engineered to burst at the leak site, mixing the two glue components and creating a sticky protein plug to repair the pipe.
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==Microbischer  zwei komponenten kleber zur selbstheilung von rohren; Der Pico-Plumber==
 
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Zussamenfassung  fuer laien:  In diesem Sythetischem Biologie projekt wird ein bakterium aus  dem menschlichem darm, Escherichia coli, genetisch manipuliert, um undichtheiten spezifisch in rohren zu entdecken und zu schliessen.
 
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Die genetisch veranderte E.coli soll undichtheiten finden indem sie ein bestimmtes chemisches signal erkennt, das an dem ort der undichtheit ausgeschuetted wird.
 
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Waehrend die bakterien sich auf die undichtheit zubewegen, fangen sie an zwei proteine zu produzieren, das erste von welchen auserhalb der celle an der cell-wand aufbewahrt wird, waehrend das andere in der cell bleibt. Diese zwei proteine representieren die zwei komponenten eines biologischen protein kleber, dessen kleb-funktion nur  hervortritt wenn die beiden komponenten zussamenkommen. Die E.coli cellen sollen so konstruiert werden das sie platzen wenn sie and der undichten stelle ankommen. Dies bringt die zwei komponenten dazu zussamenzukommen und eine klebriesche protein mixture zu erschaffen die das rohr dicht macht.
 
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এখানকার ধনী পোলাপান পড়ালেখা করে কম, পয়সা ওড়ায় বেশি। তাদের এসাইনমেন্ট লিখে দিয়েও বেশ টু-পাইস কামানো যায়।(…)
 
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<a href="https://2009.igem.org/Team:Aberdeen_Scotland"><img src="https://static.igem.org/mediawiki/2009/e/ed/Aberdeen_Left_arrow.png">&nbsp;&nbsp;Back to Top</a>
 
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<a href="https://2009.igem.org/Team:Aberdeen_Scotland/OurTeam">Our Team&nbsp;&nbsp;<img src="https://static.igem.org/mediawiki/2009/4/4c/Aberdeen_Right_arrow.png"></a>
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<a href="https://2009.igem.org/Team:Aberdeen_Scotland/Project">Start on your journey into the fantastical world of the Magical Pico Plumber&nbsp;&nbsp;<img src="https://static.igem.org/mediawiki/2009/4/4c/Aberdeen_Right_arrow.png"></a>
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Latest revision as of 09:21, 17 September 2009

University of Aberdeen iGEM 2009



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Microbial two-component glue to engineer self-healing pipes; The Pico-Plumber

Layperson Summary: This synthetic biology project will engineer a bacterium from the human gut, Escherichia coli, to detect and fix leaking pipes. Engineered E. coli will detect leaks by homing in on a chemical signal released at the leak site. As the bacteria migrate towards the leak, they will synthesise two proteins, one on the outside of the cell, the other inside, which represent the two components of a biological, protein glue. The adhesive is only activated when the two components mix. The E. coli cells will be engineered to burst at the leak site, mixing the two glue components and creating a sticky protein plug to repair the pipe.


Start on your journey into the fantastical world of the Magical Pico Plumber  

 

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