Team:Imperial College London/M2/YgiV

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===YgiV===
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<b>Background:</b>
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YgiV is a transcription factor that represses a second transcription factor called YncC. This second transcription factor blocks a third protein called YbiM. YbiM is a periplasmic protein that induces excess colanic acid production and inhibits biofilm formation.
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In nature, the colanic acid synthesis phase occurs prior to biofilm formation. The latter process of biofilm formation is associated with the upregulation of a number of virulence factors. The transcription factor YgiV blocks the progression into biofilm formation by maintaining colanic acid production. Thus YgiV serves to increase acid resistance and decrease virulence.
 
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[[Image:YgiV.png|left|300px]]
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By overexpressing YgiV, we hope to amplify the effect of RcsB while also preventing biofilm formation.
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Latest revision as of 23:31, 19 October 2009

YgiV

YgiV is a transcription factor that represses a second transcription factor called YncC. This second transcription factor blocks a third protein called YbiM. YbiM is a periplasmic protein that induces excess colanic acid production and inhibits biofilm formation.


YgiV.png


By overexpressing YgiV, we hope to amplify the effect of RcsB while also preventing biofilm formation.











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