Team:NTU-Singapore/Notebook/Brainstorming

Experiment Timeline

Health & medicine

• Create an insulin delivery system which response to low glucose level or time controlled release

• Vitamin synthesis?

• Hinder carcinogenics
  • Maslinic acid (olive skin)-tritrepenoid compound
  • Can we study anti-tumoral and apoptotic effect of this compound?
  • E coli to interfere in the carcinogenic pathways
  • Mimic the maslinic effect to the carcinogenic cells?
  • Surface markers?

•  Trap parasites in host cells by disabling the protease
  • Can we remove the trap parasites?
  • Terminate parasites?

• Genetic modified bacteria that have anticoagulant properties.

• Eczema relief

• Bacteria to treat gangrene
  • To eat up dead tissues
  • Bacteria to deliver growth factors

• Collagen producing bacteria

• Bacteria that absorbs cholesterol

• Constipation pill

• Synthesis specific growth factors

• Bacteria that produce PDGF

• Using bacteria to breakdown blockage in blood vessels

• Malaria vaccine
  •  Forcibly expresses a certain gene and create a vaccine against it
  • Proof of concept

• Cancer treatment - colon cancer(CA marker)
  • Fusion protein to signal the expression of perforin (e coli as NKC)

• Streptococcus vaccine

• p-Falciparum gene expression stabilization for malaria

• Intestinal vaccine delivery

• Bacteria to target the larvae

• To separate Tamoxifen (possibly a chiral drug) by uptake the drugs into modified E Coli and bind it to the receptor inside the bacteria.

Biosensor

• Biosensor that sense the present of allergen and release drugs to prevent allergenic response

• Mimic allergy response-to determine allergen?

•  Fingerprint detection

•  Can cells response to magnetic fields?
  • Bird GPS ??
  • Magnetic field biosensor

•  Biosensor to detect cancer

Environmental

• E coli to detect toxins in food and flu strain in animals.

• Biomask
  •  For absorption

• Create a water purifying system that recognize and trap toxic
  • to uptake salt and others- sea water purification

• Bacteria producing water for the use of photosynthesis so that plants can grow well in dry area
  • Is it possible to construct water using certain metabolism pathway?

Signalling

• Multi-color display according to inputs
  • to improve signal inputs
• DNA methylation as memory storage
• suffocate the cells
• baccine
• To construct guiding E Coli that guide pathogenic bacteria to a region of toxin/UV light.

Application

• bacterial barometer
• fill up crack
• dust repel
• microscopic spring-using spirobac
• To construct a Sound sensing bacteria

Modeling

• modeling the trend of evolution of flu viruses

Bioproduction

• Methanol in E-coli