Team:BCCS-Bristol/Modeling/Population Dynamics

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Revision as of 11:11, 20 July 2009

BCCS-Bristol
iGEM 2009

Population Dynamics

We are trying to find answers to these problems and questions:

Bacteria change [http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2134870&blobtype=pdf size].
- Minimum size
  - When the bacterium will be at the minimum size?
  - How fast the bacterium increase its dimension?
- Maximum size
  - When the bacterium will be to the maximum size?
- There is same relationship between [http://books.google.co.uk/books?id=0SPMLpTxGpMC&pg=PA51&lpg=PA51&dq=e.coli+size+velocity+motion&source=bl&ots=rqCBRQ1IN1&sig=__zft5KeWbLpUodXwGcyvnOBQtM&hl=en&ei=ZUhkSprSKcaZjAeN6IUC&sa=X&oi=book_result&ct=result&resnum=5 velocity and size] ?
- Relationship beetwen size/time/growth rate

Separation.
- When this happen?
- Where the bacterium get placed?
  - Maybe following the [http://books.google.co.uk/books?id=DjdgXGLoJY8C&printsec=frontcover&dq=E.+coli+in+motion++By+Howard+C.+Berg&source=gbs_similarbooks_s&cad=1 bacterium motion] ?
  - Random?
  - Fluid dynamics?
- Motion properties after the separation.
  - Velocity after separation.
- The two bacteria after the separation have the same size?

Genetic information
- After the separation the two bacteria have the same genetic properties:
  - same replication time distribution?
  - or the new one has a normal/uniform distribution on the normal/uniform distribution of the oldest one?

Growth
- Rate of growth
- Connection between the rate of duplication and the growth phase.

Standing phase
- One bacterium can "kill" another one to make its replication?
  - If yes which one is going to die?

Environment
- we can try to model a variable condition of the environment:
  - 100% Suitable for the replication of the bacteria
  - 80% Suitable for the replication of the bacteria
  - and so on...

Problems

The most popular replication time for an E.Coli is about 20/25 minutes.
Can our simulation take so long time?
How can we simulate on "world" day with 400 bacteria?

@@ Line 17: / Line 17: @@
 **When this happen?
 **Where the bacterium get placed?
-***Maybe following the bacterium motion?
+***Maybe following the [http://books.google.co.uk/books?id=DjdgXGLoJY8C&printsec=frontcover&dq=E.+coli+in+motion++By+Howard+C.+Berg&source=gbs_similarbooks_s&cad=1 bacterium motion] ?
 ***Random?
 ***Fluid dynamics?