"
Team:Imperial College London/Stomach
From 2009.igem.org
(Difference between revisions)
JamesField (Talk | contribs) |
JamesField (Talk | contribs) (→Caspase 1) |
||
| Line 34: | Line 34: | ||
==Caspase 1== | ==Caspase 1== | ||
| + | Found in small intestine & colon | ||
{{Imperial/09/Division}} | {{Imperial/09/Division}} | ||
Revision as of 17:02, 28 September 2009
Human Digestive Proteases:
- Pepsin = stomach
- Trypsin = duodenum
- Chymotrypsin
- Carboxypeptidase
Pepsin
- Released by chief cells in the stomach.
- Expressed as a zymogen pepsinogen.
- Pepsinogen is converted to pepsin by HCl which is released by parietal cells of the stomach.
- Cleaves at the N-terminus after aromatic amino acids such as phenylalanine, tryptophan, and tyrosine.
- Optimum pH of 1.5 to 2. Pepsin denatures when the pH is more than 5.0.
Caspase 1
Found in small intestine & colon
Duodenum = Endopeptidases (trypsin, chymotryopsin, elastase)
Exopeptidases (carboxypeptidases A & B)
Enteropeptidase
Small Intestine = Aminopeptidase N
Dipeptidyl aminopeptidase IV
Aminopeptidase P
Carboxypeptidase P
Angotensin-converting enzyme
Glutamyl aminopeptidase
