Team:Imperial College London/PAH

From 2009.igem.org

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(→Phenylalanine Hydroxylase Detail)
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This applet allows you to visualise the PAH 3D structure.  
This applet allows you to visualise the PAH 3D structure.  
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<script type="text/javascript" src="http://jmol.sourceforge.net/jmol/Jmol.js"></script>
 
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jmolInitialize("http://www.rcsb.org//pdb/Viewers/jmol-11.6/",true);
 
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    jmolSetCallback("loadStructCallback","myStructCallback");
 
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    jmolSetCallback("pickCallback",      "myPickCallback");
 
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    jmolSetAppletColor("white");
 
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    jmolApplet(550, "load http://www.rcsb.org//pdb/files/1DMW.pdb1.gz;select all;spacefill off; wireframe off;cartoon;color cartoon chain;select ligand;wireframe 40;spacefill 120;select all;model 0;");
 
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{{Imperial/09/TemplateBottom}}

Revision as of 08:33, 2 October 2009

Phenylalanine Hydroxylase Detail

II09 PAH Action.png


Phenylalanine Hydroxylase is an enzyme that catalyses the converstion of phenylalanine to tyrosine. This is conversion is by the addition of a hydroxyl group to the end of the 6-carbon ring of phenylalanine, to form tyrosine.

Since PAH is usually found in the liver, it unsurprisingly lacks any natural resistance to proteases found in the intestine. In order to overcome this problem we introduced a mutation into the structure of PAH to increase its resistance to proteolytic degradation. The delivery of PAH by The Encapsulator is particularly relevant on two accounts. Firstly, it represents a landmark in metabolic subcontraction and secondly, it offers a treatment for a genetic disease.


Phenylalanine Hydroxylase Model

This applet allows you to visualise the PAH 3D structure.


Mr. Gene   Geneart   Clontech   Giant Microbes

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