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Team:Imperial College London/Drylab/Autoinduction
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* This is a cybernetic model developed by Kompala et al [1]. | * This is a cybernetic model developed by Kompala et al [1]. | ||
* It is based on Michaelis-Menten assumptions for substrate consumption. | * It is based on Michaelis-Menten assumptions for substrate consumption. | ||
| + | * The substrates in this case are our carbon sources: glucose, maltose, xylose, galactose... | ||
| + | <br> | ||
| + | <b>Rationale:</b><br> | ||
===Model 2=== | ===Model 2=== | ||
Revision as of 19:20, 8 October 2009
Autoinduction
Starting the encapsulation process is related to diauxic growth of bacteria under two carbon sources. This is explained further here. 2 models have been discussed in this section and more information about each can be found in the tabs.
Contents |
Goal of the models
- Provide understanding of the [http://en.wikipedia.org/wiki/Diauxie diauxic growth] phenomenon
- Find out the time taken to consume glucose in the medium to characterize the CRP promoter.
Model 1
- This is a cybernetic model developed by Kompala et al [1].
- It is based on Michaelis-Menten assumptions for substrate consumption.
- The substrates in this case are our carbon sources: glucose, maltose, xylose, galactose...
Rationale:
Model 2
Details coming up soon! Still running long simulations...
References
[1]Kompala, D.S., D. Ramkrishna and G.T. Tsao, "Cybernetic modeling of microbial growth on multiple substrates," Biotechnology and Bioengineering 26 :1272-1281 (1984).
[2] Zhao Lu et al. "Dynamics of Glucose-Lactose Diauxic Growth in E.coli". arXiv:0708.1993v1 [q-bio.OT] 15 Aug 2007
