Team:Imperial College London/Autoinduction

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Module Integration - Autoinduction




Initiation

Module 2 is triggered by a rise in levels of cyclic Adenosine Mono Phosphate (cAMP). This is because cAMP facilitates the dimerisation of the transcription factor CRP which induces transcription downstream of the PcstA promoter. The rise in cAMP is correlated with a fall in levels of the primary carbon source (glucose). Thus, by controlling the initial amount of glucose present in the system, we achieve a timer function for the start of Module 2.

  About Module 2 temporal control.




Results

Mr. Gene   Geneart   Clontech   Giant Microbes