Team:Imperial College London/Stomach

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Contents

Human Digestive Proteases:

  • Pepsin = stomach
  • Trypsin = duodenum
  • Chymotrypsin
  • Carboxypeptidase



Stomach

Pepsin

  • Released by chief cells in the stomach.
  • Expressed as a zymogen pepsinogen.
  • Pepsinogen is converted to pepsin by HCl which is released by parietal cells of the stomach.
  • Cleaves at the N-terminus after aromatic amino acids such as phenylalanine, tryptophan, and tyrosine.
  • Optimum pH of 1.5 to 2. Pepsin denatures when the pH is more than 5.0.



Duodenum

Endopeptidases (trypsin, chymotryopsin, elastase)

Exopeptidases (carboxypeptidases A & B)

Enteropeptidase

Trypsin

Chymotryopsin

Elastase

Carboxypeptidases A & B




Small Intestine = Aminopeptidase N

Dipeptidyl aminopeptidase IV

Aminopeptidase P

Carboxypeptidase P

Angotensin-converting enzyme

Glutamyl aminopeptidase



Mr. Gene   Geneart   Clontech   Giant Microbes

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