Team:NTU-Singapore/Notebook/Brainstorming

Experiment Timeline

Health & medicine

• Create an insulin delivery system which response to low glucose level or time controlled release
• Vitamin synthesis?
• Hinder carcinogenics
  • Maslinic acid (olive skin)-tritrepenoid compound
  • Can we study anti-tumoral and apoptotic effect of this compound?
  • E coli to interfere in the carcinogenic pathways
  • mimic the maslinic effect to the carcinogenic cells?
  • surface markers?
•  trap parasites in host cells by disabling the protease
  • Can we remove the trap parasites?
  • Terminate parasites?
• genetic modified bacteria that have anticoagulant properties.
• eczema relief
• bacteria to treat gangrene
  • to eat up dead tissues
  • bac to deliver growth factors
• collagen producing bacteria
• bacteria that absorbs cholesterol
• constipation pill
• synthesis specific growth factors
• bacteria tt produce PDGF
• using bacteria to breakdown blockage in blood vessels
• malaria vaccine
  •  forcibly experesses a certain gene and create a vaccine against it
  • to prove the concept
• cancer treatment-colon cancer(CA marker)
  • fusion protein to signal the expression of perforin (e coli as NKC)
• streptococcus vaccine
• p-falciparum gene expression stabilization ; Malaria
• intestinal vaccine delivery
• bac to target the larvae; Malaria
• To separate Tamoxifen (possibly a chiral drug) by uptake the drugs into modified E Coli and bind it to the receptor inside the bacteria.

Biosensor

• biosensor that sense the present of allergen and release drugs to prevent allergenic response
• Mimic allergy response-to determine allergen?
•  fingerprint detection
•  Can cells response to magnetic fields?
  • Bird GPS ??
  • magnetic field biosensor
•  biosensor to detect cancer

Environmental

• E coli to detect toxins in food and flu strain in animals.
• Biomask
  •  For absorption
• create a water purifying system that recognize and trap toxic
  • to uptake salt and others- sea water purification
• bacteria producing water for the use of photosynthesis so that plants can grow well in dry area
  • is it possible to construct water using certain metabolism pathway?

Signalling

• Multi-color display according to inputs
  • to improve signal inputs
• DNA methylation as memory storage
• suffocate the cells
• baccine
• To construct guiding E Coli that guide pathogenic bacteria to a region of toxin/UV light.

Application

• bacterial barometer
• fill up crack
• dust repel
• microscopic spring-using spirobac
• To construct a Sound sensing bacteria

Modeling

• modeling the trend of evolution of flu viruses

Bioproduction

• Methanol in E-coli