"
Team:Imperial College London/Biobricks
From 2009.igem.org
Biobricks
| Registry Code | Type | Sequence Description | |
|---|---|---|---|
| Coding | RcsB. RcsB is a receiver protein in a two component phosphorelay system, which acts as a positive regulator of a number of genes including capsule genes responsible for colanic acid production. This is via the activation of the ugd/cps operon which is required for capsule synthesis. Colanic acid is a heteropolymer containing glucose, galactose, fucose, and glucuronic acid. It is important to note that RcsB is a global regulator found in many Enterobacteria. In Salmonella, up to 38 genes were found to be up-regulated by RcsB including ftsZ which affects the rate of cell division. The majority of upregulated genes are associated with enhancing structural integrety and acid resistance. 22 genes were found to be downregualted by RcsB in the same microarray experiment. | ||
