Team:Imperial College London/Drylab/Autoinduction

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Autoinduction

II09 diauxi illust.jpg

Starting the encapsulation process is related to diauxic growth of bacteria under two carbon sources. This is explained further here. 2 models have been discussed in this section and more information about each can be found in the tabs.

Contents

Goal of the models

  • Provide understanding of the [http://en.wikipedia.org/wiki/Diauxie diauxic growth] phenomenon
  • Find out the time taken to consume glucose in the medium to characterize the CRP promoter.

Model 1

  • This is a cybernetic model developed by Kompala et al [1].
  • It is based on Michaelis-Menten assumptions for substrate consumption.

Model 2

Details coming up soon! Still running long simulations...

References

[1]Kompala, D.S., D. Ramkrishna and G.T. Tsao, "Cybernetic modeling of microbial growth on multiple substrates," Biotechnology and Bioengineering 26 :1272-1281 (1984).
[2] Zhao Lu et al. "Dynamics of Glucose-Lactose Diauxic Growth in E.coli". arXiv:0708.1993v1 [q-bio.OT] 15 Aug 2007

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