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Team:BCCS-Bristol/Meetings/July
From 2009.igem.org
iGEM 2009
Contents |
30th July 2009
The focus of this meeting was to finalize the project proposal, now found at Team:BCCS-Bristol/Project. On the modelling side, we delegated GRNs to Petros/Antos, vesicles to Steve, magnetotaxis to Emily and performance/population dynamics to Mattia. Lab work progresses.
23rd July 2009
The project has gained a direction and a lot of work has been done in both modelling and wet-lab aspects. A review of the project and its goals was given to all advisors and views about further work.
We are improving BSim to have a more "real-life" feeling. Current progress includes the shape of bacteria and population dynamics.
A copy of the presentation can be found here. The tangible progress in the wetlab is expanded in this presentation found here.
16th July 2009
Discussed the progress of the project. We are currently focused on the vesicle formation part of the project although some steps have been taken in trying to develop magnetotaxis ex vivo.
The relevant presentation can be found here.
9th July 2009
Vesicles with a twist...part II
After a week's worth of digging through the literature we have managed to find possible non-toxic candidate proteins that pack within outer membrane vesicles produced by E.coli. Thus we have settled into implementing directed communication and delivery of proteins of interest between different cells/populations. This will possibly form the bigger part of the project and if time permits we will combine this with our magnetotaxis idea.
With respect to modelling we are interested in developing a useful tool for the community and research by possibly expanding the existing BSim software. For further information visit the modelling page of the wiki.
With respect to the lab we will pursuit the building of biobricks that will allow the implementation of proteins of interest into OMVs (outer membrane vesicles) as a first part to the project. Upon the succesful completion of this first task we want to implement some GRN for the control of responses of both production and/or message acceptance.
A copy of the presentation of this meeting can be found here.
2nd July 2009
Vesicles with a twist
We seem to have settled down to the idea that implementing magnetotaxis in vivo in E.coli will be infeasible within the given time-frame. Instead we have decided to move in the direction where we will try implementing the usage of vesicles in our project.
We are still thinking of perhaps implementing magnetotaxis combined with bacteria in an in vitro manner.
