Team:Groningen/Brainstorm/Growth Control

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Home	The Team	Brainstorm	Our Vision	Parts	Modelling	Notebook

Introduction

Under construction

Previous contests

Cell cycle

[http://parts.mit.edu/wiki/index.php/Synchronization_of_Cell_Cycles| Bangalore 2006]
Strasbourg 2008

Parts in the [http://partsregistry.org/Main_Page Registry of Standard Parts]:

Quorum sensing

[http://partsregistry.org/Part:BBa_K104001 BBa_K104001]: Sensor for small peptide Subtilin
[http://partsregistry.org/Part:BBa_I13211 BBa_I13211]: Biobricked version of the natural Lux quorum sensing system

Cell cycle

[http://partsregistry.org/Part:BBa_M31201 BBa_M31201]
[http://partsregistry.org/Part:BBa_K105013 BBa_K105013]
[http://partsregistry.org/Part:BBa_K105015 BBa_K105015]
[http://partsregistry.org/Part:BBa_K101017 BBa_K101017]: a cell-cycle dependent promoter that is repressed before initiation of replication and depressed shortly after
[http://partsregistry.org/Part:BBa_J22051 BBa_J22051]: an adenylate cyclase promoter, expression is repressed during cell division
[http://partsregistry.org/Part:BBa_J22052 BBa_J22052]: an adenylate cyclase promoter, expression is repressed during cell division
[http://partsregistry.org/Part:BBa_J22095 BBa_J22095]
[http://partsregistry.org/Part:BBa_J22092 BBa_J22092]

Cell death

[http://partsregistry.org/Part:BBa_I745006 BBa_I745006]
[http://partsregistry.org/Part:BBa_I745007 BBa_I745007]
[http://partsregistry.org/Part:BBa_K145008 BBa_K145008]: LuxR Generator
[http://partsregistry.org/Part:BBa_K145009 BBa_K145009]: ccdB cell death gene under control of an activating Lux PR
[http://partsregistry.org/Part:BBa_K145109 BBa_K145109]: ccdB cell death gene under the control of a hybrid LuxPR P22 C2 promotor
[http://partsregistry.org/Part:BBa_K145110 BBa_K145110]: Complete cell death mechanism. Combination of [http://partsregistry.org/Part:BBa_K145108 BBa_K145108] and [http://partsregistry.org/Part:BBa_K145109 Part:BBa_K145109]
[http://partsregistry.org/Part:BBa_K145151 BBa_K145151]: Coding region for the ccdB (control of cell death) gene
[http://partsregistry.org/Part:BBa_K145230 BBa_K145230]: A hybrid promoter controls the production of LuxR and ccdB
[http://partsregistry.org/Part:BBa_K145256 BBa_K145256]: Cell death Part 1
[http://partsregistry.org/Part:BBa_K145257 BBa_K145257]: Cell death Part 2

Related Literature

Quorum sensing

[http://www.ncbi.nlm.nih.gov/pubmed/15374644 Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis], Kleerebezem

In this paper, the molecular mechanism underlying regulation of nisin and subtilin production is reviewed.

[http://www.ncbi.nlm.nih.gov/pubmed/9675856 Induction of entry into the stationary growth phase in Pseudomonas aeruginosa by N-acylhomoserine lactone], You et al.

Addition of N-acylhomoserine lactone in the exponential growth phase, regardless of cell density, induces a repression of cell growth of P. aeruginosa

[http://www.ncbi.nlm.nih.gov/pubmed/12032343 Induction of natural competence in Streptococcus pneumoniae triggers lysis and DNA release from a subfraction of the cell population], Steinmoen et al.

In this study Competence stimulating peptide is shown to initiates release of DNA from a subfraction of the bacterial population, probably by cell lysis.