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Team:SDU-Denmark
From 2009.igem.org
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=Bacto-Bandage= | =Bacto-Bandage= | ||
Revision as of 16:47, 23 July 2009
About | Background | Project | Parts | Team
Diary | Protocols | Downloads | Brainstorm
About our project
Bacto-Bandage
Our goal is to create an E. coli strain, which inhibits Staphylococcus aureus (S. aureus) biofilm formation in wounds by producing RNA III-inhibiting-peptide (RIP).
S. aureus is one of the largest causes of hospital infections, each year infecting millions of people around the globe. S. aureus is normally commensal, but can create bacterial biofilms on implanted medical devices and in post-operational wounds. Biofilm is becoming increasingly hard to treat, as a result of growing resistance to many types of antibiotics.
By manipulating E. coli to express a synthetic RIP peptide tagged with an export signal, we hope to reach this goal. RIP has been shown to hinder the quorum-sensing processes essential for biofilm development in S. aureus*, thereby making it harder for the bacteria to spread and cause infections. We also propose making a bandage that contains our engineered bacteria behind a semipermeabel membrane, allowing only our RIP peptides to pass through, into the wound.
Read more about our project | Read more about the background
About our team
University of Southern Denmark
We are eight students from the University of Southern Denmark, who shared a common wish to explore synthetic biology and decided to start the first iGEM team at our university.
Together with six advisors, we are spending the summer getting to grips with the up’s and down’s in synthetic biology, the lab, how to organize the project and everything in between.
Read more about our team | See what we're up to on our blog
