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Team:TUDelft/Brainstorm
From 2009.igem.org
(Difference between revisions)
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| - | ==Impulse Signal== | + | ===Impulse Signal=== |
* one suggestion (by Federico_C) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code. | * one suggestion (by Federico_C) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code. | ||
| - | ==Water Soluble Vitamin Production== | + | ===Water Soluble Vitamin Production=== |
* produce Vitamins B and C. | * produce Vitamins B and C. | ||
| - | ==Stop Quorum Signalling -> Quenching AHL== | + | ===Stop Quorum Signalling -> Quenching AHL=== |
* aiiA enzyme [http://www.msk.or.kr/jsp/view_old_journalD.jsp?paperSeq=2133] already has a biobrick [http://partsregistry.org/Part:BBa_C0060 Part:BBa_C0060] but it is not secreted. | * aiiA enzyme [http://www.msk.or.kr/jsp/view_old_journalD.jsp?paperSeq=2133] already has a biobrick [http://partsregistry.org/Part:BBa_C0060 Part:BBa_C0060] but it is not secreted. | ||
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| - | ==Biological Isotope Separation== | + | ===Biological Isotope Separation=== |
* is it even possible? | * is it even possible? | ||
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* possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food. | * possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food. | ||
| - | * another paper is | + | * another paper is ''Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. '' havent found a copy online. |
| - | ==Saltwater Purification== | + | ===Saltwater Purification=== |
* + heavy metal extraction | * + heavy metal extraction | ||
| Line 59: | Line 59: | ||
| - | ==Xylitol production== | + | ===Xylitol production=== |
* already attempted, see [http://openwetware.org/images/0/03/6-bolaji.pdf] | * already attempted, see [http://openwetware.org/images/0/03/6-bolaji.pdf] | ||
| - | ==Melatonin Compensation== | + | ===Melatonin Compensation=== |
* compensate the reduction in melatonin levels caused by the invention of electrical lights | * compensate the reduction in melatonin levels caused by the invention of electrical lights | ||
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| - | ==New Antibiotic Cassettes== | + | ===New Antibiotic Cassettes=== |
* Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline. | * Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline. | ||
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| - | ==Paper Based Microfluidics with bacteria== | + | ===Paper Based Microfluidics with bacteria=== |
* Improve the processing outlined in [http://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.cfm?JournalCode=LC&Year=2008&ManuscriptID=b811135a&Iss=12 FLASH: A rapid method for prototyping paper-based microfluidic devices], see papers from Whitesides group at Harvard. | * Improve the processing outlined in [http://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.cfm?JournalCode=LC&Year=2008&ManuscriptID=b811135a&Iss=12 FLASH: A rapid method for prototyping paper-based microfluidic devices], see papers from Whitesides group at Harvard. | ||
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| - | ==Close proximity phage expression== | + | ===Close proximity phage expression=== |
* once a cell is close enough to a target, produce phages and explode | * once a cell is close enough to a target, produce phages and explode | ||
| - | ==Anti-Venom System== | + | ===Anti-Venom System=== |
* inject bacteria after being bitten | * inject bacteria after being bitten | ||
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| - | ==Birth Control Yoghurt== | + | ===Birth Control Yoghurt=== |
* attacks sperm | * attacks sperm | ||
| Line 108: | Line 108: | ||
| - | ==Buoyant Bacteria== | + | ===Buoyant Bacteria=== |
* for metal extraction from old mines or ocean | * for metal extraction from old mines or ocean | ||
| - | ==Excrement Degradation Bacteria== | + | ===Excrement Degradation Bacteria=== |
* dog excrements degrades quickly | * dog excrements degrades quickly | ||
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| - | ==Additional Processing of Excretion for Energy== | + | ===Additional Processing of Excretion for Energy=== |
* Zero Growth -> convert everything to product | * Zero Growth -> convert everything to product | ||
| - | ==Targeted Delivery== | + | ===Targeted Delivery=== |
* use THC for medical benefits without any psychoactive effects | * use THC for medical benefits without any psychoactive effects | ||
| - | ==microRNA and P53== | + | ===microRNA and P53=== |
* inhibit miRNA to increase activity of tumor-suppressor gene p53 | * inhibit miRNA to increase activity of tumor-suppressor gene p53 | ||
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| - | ==Synchronization -> Flashing Colony== | + | ===Synchronization -> Flashing Colony=== |
* synchronized flashing | * synchronized flashing | ||
| Line 144: | Line 144: | ||
| - | ==Sensor Reporter Spatially Displaced== | + | ===Sensor Reporter Spatially Displaced=== |
| - | ==Kalman Filter== | + | ===Kalman Filter=== |
* integrate into larger project | * integrate into larger project | ||
| - | ==Stopping a Cytokine storm== | + | ===Stopping a Cytokine storm=== |
* something which could break the feedback loop in a cytokine storm | * something which could break the feedback loop in a cytokine storm | ||
Revision as of 11:48, 27 April 2009
Brainstorm area
Interesting Links:
[http://openwetware.org/wiki/IGEM:Idea_exchange iGEM Idea Exchange]
[http://openwetware.org/wiki/Tk:wanted_parts TK: Wanted Parts]
[http://openwetware.org/wiki/IGEM:Projects_categorized iGEM:Projects categorized]
[http://openwetware.org/wiki/Synthetic_Biology:Vectors/Wishlist Synthetic_Biology:Vectors/Wishlist]
Impulse Signal
- one suggestion (by Federico_C) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code.
Water Soluble Vitamin Production
- produce Vitamins B and C.
Stop Quorum Signalling -> Quenching AHL
- aiiA enzyme [http://www.msk.or.kr/jsp/view_old_journalD.jsp?paperSeq=2133] already has a biobrick [http://partsregistry.org/Part:BBa_C0060 Part:BBa_C0060] but it is not secreted.
- halogenated furanones [http://mic.sgmjournals.org/cgi/content/full/151/11/3589?view=long&pmid=16272381] [http://mic.sgmjournals.org/cgi/content/full/148/4/1119?view=long&pmid=11932456] decrease binding activity of LuxR.
- [http://www.molbio.princeton.edu/index.php?option=content&task=view&id=27 Bonnie Bassler]'s research, inhibit quorum signaling with molecules structurally similar to AHL. Her recent [http://www.ted.com/index.php/talks/bonnie_bassler_on_how_bacteria_communicate.html TED Talk].
Biological Isotope Separation
- is it even possible?
- according to this [http://jol.liljenzin.se/BOOK.HTM book] in section 2.6.5. [http://jol.liljenzin.se/KAPITEL/CH02NY3.PDF], both chlorella algae and E.coli have isotope enrichment properties (hydrogen, deuterium). no references given.
- possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food.
- another paper is Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. havent found a copy online.
Saltwater Purification
- + heavy metal extraction
- diatoms
- Dead Sea organisms
Xylitol production
- already attempted, see [http://openwetware.org/images/0/03/6-bolaji.pdf]
Melatonin Compensation
- compensate the reduction in melatonin levels caused by the invention of electrical lights
- has been linked to lots of medical problems, see review paper [http://www.psy.ohio-state.edu/nelson/documents/JPinealRes2007.pdf The dark side of light at night: physiological, epidemiological, and ecological consequences]
- would need to implement melatonin detection, synthesis, and a clock
New Antibiotic Cassettes
- Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline.
- New biobricks needed (see TK:Wishlist), integrate into larger project?
- Cationic peptides, Rhodostreptomycins [http://mit.edu/biology/sinskey/www/Kurosawa2008.pdf]
Paper Based Microfluidics with bacteria
- Improve the processing outlined in [http://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.cfm?JournalCode=LC&Year=2008&ManuscriptID=b811135a&Iss=12 FLASH: A rapid method for prototyping paper-based microfluidic devices], see papers from Whitesides group at Harvard.
- use light sensor and output hydrophobic/hydrophilic chemicals that can coat the cellulose in the paper placed on an agar plate
Close proximity phage expression
- once a cell is close enough to a target, produce phages and explode
Anti-Venom System
- inject bacteria after being bitten
- sense which venom and produce proper anti-venom
Birth Control Yoghurt
- attacks sperm
- animal use
Buoyant Bacteria
- for metal extraction from old mines or ocean
Excrement Degradation Bacteria
- dog excrements degrades quickly
- can be used in as excrement degrader instead of waste tank in portable toilets or [http://en.wikipedia.org/wiki/Deodorize deodorizing] excrements in chemical toilets
Additional Processing of Excretion for Energy
- Zero Growth -> convert everything to product
Targeted Delivery
- use THC for medical benefits without any psychoactive effects
microRNA and P53
- inhibit miRNA to increase activity of tumor-suppressor gene p53
- needs targeted delivery system
Synchronization -> Flashing Colony
- synchronized flashing
- covalent modification
Sensor Reporter Spatially Displaced
Kalman Filter
- integrate into larger project
Stopping a Cytokine storm
- something which could break the feedback loop in a cytokine storm
