Team:TUDelft/Brainstorm
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* make a group of cells contract | * make a group of cells contract |
Revision as of 20:23, 6 May 2009
Brainstorm Area
Interesting Links
Interesting Papers (provided by Domenico)
- Design and Construction of a Double Inversion Recombination Switch for Heritable Sequential Genetic Memory
- A tunable synthetic mammalian oscillator
- Programming gene expression with combinatorial promoters
- Photoreceptor Proteins, “Star Actors of Modern Times”: A Review of the Functional Dynamics in the Structure of Representative Members of Six Different Photoreceptor Families
- Environment-specific combinatorial cis-regulation in synthetic promoters
- Implementing Arithmetic and Other Analytic Operations By Transcriptional Regulation
- Engineering BioBrick vectors from BioBrick parts
- Model-guided design of ligand-regulated RNAi for programmable control of gene expression
- Diversity-based, model-guided construction of synthetic gene networks with predicted functions
Brainstorm Ideas
Impulse Signal
- one suggestion (by Federico C.) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code.
Water Soluble Vitamin Production
- produce Vitamins B and C.
Stop Quorum Signalling -> Quenching AHL
- aiiA enzyme [1] already has a biobrick Part:BBa_C0060 but it is not secreted.
- Bonnie Bassler's research, inhibit quorum signaling with molecules structurally similar to AHL. Her recent TED Talk.
Biological Isotope Separation
- is it even possible?
- according to this book in section 2.6.5. [4], both chlorella algae and E.coli have isotope enrichment properties (hydrogen, deuterium). no references given.
- possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food.
- another paper is Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. havent found a copy online.
Saltwater Purification
- + heavy metal extraction
- diatoms
- Dead Sea organisms
Xylitol production
- already attempted, see [5]
Melatonin Compensation
- compensate the reduction in melatonin levels caused by the invention of electrical lights
- has been linked to lots of medical problems, see review paper The dark side of light at night: physiological, epidemiological, and ecological consequences
- would need to implement melatonin detection, synthesis, and a clock
New Antibiotic Cassettes
- Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline.
- New biobricks needed (see TK:Wishlist), integrate into larger project?
- Cationic peptides, Rhodostreptomycins [6]
Paper Based Microfluidics with bacteria
- Improve the processing outlined in FLASH: A rapid method for prototyping paper-based microfluidic devices, see papers from Whitesides group at Harvard.
- use light sensor and output hydrophobic/hydrophilic chemicals that can coat the cellulose in the paper placed on an agar plate
Close proximity phage expression
- once a cell is close enough to a target, produce phages and explode
Anti-Venom System
- inject bacteria after being bitten
- sense which venom and produce proper anti-venom
Birth Control Yoghurt
- attacks sperm
- animal use
Buoyant Bacteria
- for metal extraction from old mines or ocean
Excrement Degradation Bacteria
- dog excrements degrades quickly
- can be used in as excrement degrader instead of waste tank in portable toilets or deodorizing excrements in chemical toilets
Additional Processing of Excretion for Energy
- Zero Growth -> convert everything to product
Targeted Delivery
- use THC for medical benefits without any psychoactive effects
microRNA and P53
- inhibit miRNA to increase activity of tumor-suppressor gene p53
- needs targeted delivery system
Synchronization -> Flashing Colony
- synchronized flashing
- covalent modification
Sensor Reporter Spatially Displaced
Kalman Filter
- integrate into larger project
Stopping a Cytokine storm
- something which could break the feedback loop in a cytokine storm
MicroOrganism muscle
- make a group of cells contract