Team:TUDelft/Brainstorm

From 2009.igem.org

(Difference between revisions)
(New page: {{Template:TUDelftiGEM2009}} =Brainstorm area= Interesting Links: [http://openwetware.org/wiki/IGEM:Idea_exchange iGEM Idea Exchange] [http://openwetware.org/wiki/Tk:wanted_parts TK...)
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=Brainstorm area=
=Brainstorm area=
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Interesting Links:
Interesting Links:
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[http://openwetware.org/wiki/Synthetic_Biology:Vectors/Wishlist Synthetic_Biology:Vectors/Wishlist]
[http://openwetware.org/wiki/Synthetic_Biology:Vectors/Wishlist Synthetic_Biology:Vectors/Wishlist]
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==Impulse Signal==
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* one suggestion (by Federico_C) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code.
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==Water Soluble Vitamin Production==
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* produce Vitamins B and C.
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==Stop Quorum Signalling -> Quenching AHL==
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* aiiA enzyme [http://www.msk.or.kr/jsp/view_old_journalD.jsp?paperSeq=2133] already has a biobrick [http://partsregistry.org/Part:BBa_C0060 Part:BBa_C0060] but its not secreted.
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* halogenated furanones [http://mic.sgmjournals.org/cgi/content/full/151/11/3589?view=long&pmid=16272381] [http://mic.sgmjournals.org/cgi/content/full/148/4/1119?view=long&pmid=11932456] decrease binding activity of LuxR.
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* [http://www.molbio.princeton.edu/index.php?option=content&task=view&id=27 Bonnie Bassler]'s research, inhibit quorum signaling with molecules structurally similar to AHL. Her recent [http://www.ted.com/index.php/talks/bonnie_bassler_on_how_bacteria_communicate.html TED Talk].
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==Biological Isotope Separation==
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* is it even possible?
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* according to this [http://jol.liljenzin.se/BOOK.HTM book] in section 2.6.5. [http://jol.liljenzin.se/KAPITEL/CH02NY3.PDF], both chlorella algae and E.coli have isotope enrichment properties (hydrogen, deuterium). no references given.
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* possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food.
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* another paper is '''Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. ''' havent found a copy online.
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==Saltwater Purification==
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* + heavy metal extraction
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* diatoms
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* Dead Sea organisms
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==Xylitol production==
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* already attempted, see [http://openwetware.org/images/0/03/6-bolaji.pdf]
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==Melatonin Compensation==
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* compensate the reduction in melatonin levels caused by the invention of electrical lights
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* has been linked to lots of medical problems, see review paper [http://www.psy.ohio-state.edu/nelson/documents/JPinealRes2007.pdf The dark side of light at night: physiological, epidemiological, and ecological consequences]
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* would need to implement melatonin detection, synthesis, and a clock
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==New Antibiotic Cassettes==
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* Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline.
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* New biobricks needed (see TK:Wishlist), integrate into larger project?
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* Cationic peptides, Rhodostreptomycins [http://mit.edu/biology/sinskey/www/Kurosawa2008.pdf]
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==Paper Based Microfluidics with bacteria==
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* Improve the processing outlined in [http://www.rsc.org/delivery/_ArticleLinking/ArticleLinking.cfm?JournalCode=LC&Year=2008&ManuscriptID=b811135a&Iss=12 FLASH: A rapid method for prototyping paper-based microfluidic devices], see papers from Whitesides group at Harvard.
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* use light sensor and output hydrophobic/hydrophilic chemicals that can coat the cellulose in the paper placed on an agar plate
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==Close proximity phage expression==
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* once a cell is close enough to a target, produce phages and explode
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==Anti-Venom System==
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* inject bacteria after being bitten
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* sense which venom and produce proper anti-venom
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==Birth Control Yogurt==
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* attacks sperm
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* animal use
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==Buoyant Bacteria==
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* for metal extraction from old mines or ocean
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==Excrement Degradation Bacteria==
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* dog poo degrades quickly
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==Additional Processing of Excretion for Energy==
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* Zero Growth -> convert everything to product
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==Targeted Delivery==
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* use THC for medical benefits without any psychoactive effects
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==microRNA and P53==
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* inhibit miRNA to increase activity of tumor-suppressor gene p53
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* needs targeted delivery system
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==Synchronization -> Flashing Colony==
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* synchronized flashing
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* covalent modification
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==Sensor Reporter Spatially Displaced==
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==Kalman Filter==
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* integrate into larger project
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Revision as of 20:41, 23 April 2009


Brainstorm area

Interesting Links:


iGEM Idea Exchange

TK: Wanted Parts

iGEM:Projects categorized

Synthetic_Biology:Vectors/Wishlist


Impulse Signal

  • one suggestion (by Federico_C) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code.


Water Soluble Vitamin Production

  • produce Vitamins B and C.


Stop Quorum Signalling -> Quenching AHL

  • halogenated furanones [2] [3] decrease binding activity of LuxR.
  • Bonnie Bassler's research, inhibit quorum signaling with molecules structurally similar to AHL. Her recent TED Talk.


Biological Isotope Separation

  • is it even possible?
  • according to this book in section 2.6.5. [4], both chlorella algae and E.coli have isotope enrichment properties (hydrogen, deuterium). no references given.
  • possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food.
  • another paper is Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. havent found a copy online.


Saltwater Purification

  • + heavy metal extraction
  • diatoms
  • Dead Sea organisms


Xylitol production

  • already attempted, see [5]


Melatonin Compensation

  • compensate the reduction in melatonin levels caused by the invention of electrical lights
  • would need to implement melatonin detection, synthesis, and a clock


New Antibiotic Cassettes

  • Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline.
  • New biobricks needed (see TK:Wishlist), integrate into larger project?
  • Cationic peptides, Rhodostreptomycins [6]


Paper Based Microfluidics with bacteria

  • use light sensor and output hydrophobic/hydrophilic chemicals that can coat the cellulose in the paper placed on an agar plate


Close proximity phage expression

  • once a cell is close enough to a target, produce phages and explode


Anti-Venom System

  • inject bacteria after being bitten
  • sense which venom and produce proper anti-venom


Birth Control Yogurt

  • attacks sperm
  • animal use


Buoyant Bacteria

  • for metal extraction from old mines or ocean


Excrement Degradation Bacteria

  • dog poo degrades quickly


Additional Processing of Excretion for Energy

  • Zero Growth -> convert everything to product


Targeted Delivery

  • use THC for medical benefits without any psychoactive effects


microRNA and P53

  • inhibit miRNA to increase activity of tumor-suppressor gene p53
  • needs targeted delivery system


Synchronization -> Flashing Colony

  • synchronized flashing
  • covalent modification


Sensor Reporter Spatially Displaced

Kalman Filter

  • integrate into larger project


 

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