Brainstorm area

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iGEM Idea Exchange

TK: Wanted Parts

iGEM:Projects categorized

Synthetic_Biology:Vectors/Wishlist

Impulse Signal

• one suggestion (by Federico_C) from the idea exchange was to create a self-destructing plasmid, which would express once and than destroy itself with a restriction endonuclease in its code.

Water Soluble Vitamin Production

• produce Vitamins B and C.

Stop Quorum Signalling -> Quenching AHL

• aiiA enzyme [1] already has a biobrick Part:BBa_C0060 but it is not secreted.

• halogenated furanones [2] [3] decrease binding activity of LuxR.

• Bonnie Bassler's research, inhibit quorum signaling with molecules structurally similar to AHL. Her recent TED Talk.

Biological Isotope Separation

• is it even possible?

• according to this book in section 2.6.5. [4], both chlorella algae and E.coli have isotope enrichment properties (hydrogen, deuterium). no references given.

• possible applications: remove radioactive isotopes from body (cancer treatments), separate heavy water from ocean water, remove carbon 14 and potassium 40 from body/food.

• another paper is Bioseparation of Lithium Isotopes by Using Microorganisms, Sakaguchi, Takashi | Tomita, Osamu, Resource and Environmental Biotechnology [Resour. Environ. Biotechnol.]. Vol. 3, no. 2-3, pp. 173-182. 2000. havent found a copy online.

Saltwater Purification

• + heavy metal extraction

• diatoms

• Dead Sea organisms

Xylitol production

• already attempted, see [5]

Melatonin Compensation

• compensate the reduction in melatonin levels caused by the invention of electrical lights

• has been linked to lots of medical problems, see review paper The dark side of light at night: physiological, epidemiological, and ecological consequences

• would need to implement melatonin detection, synthesis, and a clock

New Antibiotic Cassettes

• Biobricks exist for Ampicillin, Kanamycin, Chloramphenicol, and Tetracycline.

• New biobricks needed (see TK:Wishlist), integrate into larger project?

• Cationic peptides, Rhodostreptomycins [6]

Paper Based Microfluidics with bacteria

• Improve the processing outlined in FLASH: A rapid method for prototyping paper-based microfluidic devices, see papers from Whitesides group at Harvard.

• use light sensor and output hydrophobic/hydrophilic chemicals that can coat the cellulose in the paper placed on an agar plate

Close proximity phage expression

• once a cell is close enough to a target, produce phages and explode

Anti-Venom System

• inject bacteria after being bitten

• sense which venom and produce proper anti-venom

Birth Control Yoghurt

• attacks sperm

• animal use

Buoyant Bacteria

• for metal extraction from old mines or ocean

Excrement Degradation Bacteria

• dog excrements degrades quickly

• can be used in as excrement degrader instead of waste tank in portable toilets or deodorizing excrements in chemical toilets

Additional Processing of Excretion for Energy

• Zero Growth -> convert everything to product

Targeted Delivery

• use THC for medical benefits without any psychoactive effects

microRNA and P53

• inhibit miRNA to increase activity of tumor-suppressor gene p53

• needs targeted delivery system

Synchronization -> Flashing Colony

• synchronized flashing

• covalent modification

Sensor Reporter Spatially Displaced

Kalman Filter

• integrate into larger project

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