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Team:Brown
From 2009.igem.org
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| - | The 2009 Brown University iGEM team worked to treat allergic rhinitis by engineering Staphylococcus epidermidis, a microbe endogenous to the human nasal flora, to secrete a recombinant histamine-binding protein in response to the elevated histamine concentrations of an allergic response. The engineered strain of S. epidermidis will function as a self-regulating drug factory in the nose, providing relief, without any negative side effects. | + | The 2009 Brown University iGEM team worked to treat allergic rhinitis by engineering Staphylococcus epidermidis, a microbe endogenous to the human nasal flora, to secrete a recombinant histamine-binding protein in response to the elevated histamine concentrations of an allergic response. The engineered strain of S. epidermidis will function as a self-regulating drug factory in the nose, providing relief, without any negative side effects. |
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<table width="840" border="1"> | <table width="840" border="1"> | ||
<tr> | <tr> | ||
| - | <td width="167" height="166"><img src="https://static.igem.org/mediawiki/2009/8/8c/Teambutton.gif" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/8/8c/Teambutton.gif"></td> | + | <td width="167" height="166"><a href="https://2009.igem.org/Team:Brown/Team"><img src="https://static.igem.org/mediawiki/2009/8/8c/Teambutton.gif" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/8/8c/Teambutton.gif"></td> |
| - | <td width="164"><img src="https://static.igem.org/mediawiki/2009/3/33/Partsbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/3/33/Partsbutton.gif"></td> | + | <td width="164"><a href="https://2009.igem.org/Team:Brown/Parts"><img src="https://static.igem.org/mediawiki/2009/3/33/Partsbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/3/33/Partsbutton.gif"></td> |
| - | <td width="165"><img src="https://static.igem.org/mediawiki/2009/c/ce/Notebookbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/c/ce/Notebookbutton.gif"></td> | + | <td width="165"><a href="https://2009.igem.org/Team:Brown/Notebook_Weekly_Logs><img src="https://static.igem.org/mediawiki/2009/c/ce/Notebookbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/c/ce/Notebookbutton.gif"></td> |
| - | <td width="166"><img src="https://static.igem.org/mediawiki/2009/6/6e/Learnmoreallergiesbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/6/6e/Learnmoreallergiesbutton.gif"></td> | + | <td width="166"><a href="https://2009.igem.org/Team:Brown/Project_Introduction"><img src="https://static.igem.org/mediawiki/2009/6/6e/Learnmoreallergiesbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/6/6e/Learnmoreallergiesbutton.gif"></td> |
| - | <td width="156"><img src="https://static.igem.org/mediawiki/2009/9/97/Implicationsbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/9/97/Implicationsbutton.gif"></td> | + | <td width="156"><a href="https://2009.igem.org/Team:Brown/Project_Implications"><img src="https://static.igem.org/mediawiki/2009/9/97/Implicationsbutton.gif" alt="" width="150" height="100" longdesc="https://static.igem.org/mediawiki/2009/9/97/Implicationsbutton.gif"></td> |
</tr> | </tr> | ||
<tr> | <tr> | ||
| - | <td colspan="2"><img src="https://static.igem.org/mediawiki/2009/2/2a/Projectabstractbutton.gif" width="335" height="100"></td> | + | <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project"><img src="https://static.igem.org/mediawiki/2009/2/2a/Projectabstractbutton.gif" width="335" height="100"></td> |
<td colspan="3">Learn more about our project here.</td> | <td colspan="3">Learn more about our project here.</td> | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| - | <td colspan="2"><img src="https://static.igem.org/mediawiki/2009/d/d0/Histaminesensorbutton.gif" width="335" height="100"></td> | + | <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_Histamine_Sensor"><img src="https://static.igem.org/mediawiki/2009/d/d0/Histaminesensorbutton.gif" width="335" height="100"></td> |
<td colspan="3">When an allergic response occurs, our system senses a change in histamine levels. Learn more about the Histamine sensor here.</td> | <td colspan="3">When an allergic response occurs, our system senses a change in histamine levels. Learn more about the Histamine sensor here.</td> | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| - | <td colspan="2"><img src="https://static.igem.org/mediawiki/2009/3/3c/S.epibutton.gif" alt="" width="335" height="100"></td> | + | <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_S.epidermidis"><img src="https://static.igem.org/mediawiki/2009/3/3c/S.epibutton.gif" alt="" width="335" height="100"></td> |
<td colspan="3">The chassis of choice is ''Staphyloccocus Epidermidis''. Learn more about ''S.epi'' here.</td> | <td colspan="3">The chassis of choice is ''Staphyloccocus Epidermidis''. Learn more about ''S.epi'' here.</td> | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| - | <td colspan="2"><img src="https://static.igem.org/mediawiki/2009/7/70/Hbpbutton.gif" alt="" width="335" height="100"></td> | + | <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_HBP"><img src="https://static.igem.org/mediawiki/2009/7/70/Hbpbutton.gif" alt="" width="335" height="100"></td> |
<td colspan="3">rEV131 is a high-affinity histamine binding protein, that originates from the saliva of a tick. Learn more about rEV131 here.</td> | <td colspan="3">rEV131 is a high-affinity histamine binding protein, that originates from the saliva of a tick. Learn more about rEV131 here.</td> | ||
</tr> | </tr> | ||
<tr> | <tr> | ||
| - | <td colspan="2"><img src="https://static.igem.org/mediawiki/2009/1/12/Alltogetherbutton.gif" alt="" width="335" height="100"></td> | + | <td colspan="2"><a href="https://2009.igem.org/Team:Brown/Project_All_Together><img src="https://static.igem.org/mediawiki/2009/1/12/Alltogetherbutton.gif" alt="" width="335" height="100"></td> |
<td colspan="3">Learn about the big picture of our overall project here.</td> | <td colspan="3">Learn about the big picture of our overall project here.</td> | ||
</tr> | </tr> | ||
Revision as of 22:13, 21 October 2009
Every year, over fifty million people in the US suffer from allergic rhinitis, the most common type of allergy. Allergens, such as pollen, dust, and dander result in nasal congestion, itching, burning, sneezing, and overall discomfort. Current treatments include over-the-counter antihistamines, however, side effects of these drugs include drowsiness, restlessness, and poor concentration. For patients suffering from chronic allergies and inflammation, there is a great need for an alternative strategy for combating allergic symptoms without causing significant side effects.
The 2009 Brown University iGEM team worked to treat allergic rhinitis by engineering Staphylococcus epidermidis, a microbe endogenous to the human nasal flora, to secrete a recombinant histamine-binding protein in response to the elevated histamine concentrations of an allergic response. The engineered strain of S. epidermidis will function as a self-regulating drug factory in the nose, providing relief, without any negative side effects.
A special thank you to Team Heidelberg for inspiring our wiki design!
