Team:EPF-Lausanne/Team

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Revision as of 12:19, 14 July 2009

Who we are

We are a team of undergraduates with an interdisiplinary background. Most of us are from the life sciences faculty but some of us are from microengineering, mechanical engineering and chemistry.

Group : from left to right : up : Nicolas G, Christian, Gabriela, Tú, Nathalie, Carine, Nicolas D, Rafael, down : Heidi, Sebastian, Caroline, Mélanie

Advisors:

Bart Deplancke
Sebastian Maerkl
Matteo Dal Peraro
Felix Naef

Instructors:

Nicolas Dénervaud
Carine Gubelmann

Undergrads:

Christian Adamczyk
Caroline Baer
Nathalie Brandenberg
Nicolas Gobet
Mélanie Guittet
Heidi Fournier
Tú Nguyen
Rafael Pennese
Gabriela Pregernig
Basile Wicky

What we want to do

Light-sensitive proteins can easily be found in nature.

In this project, our aim is to design a fusion/hybrid protein that would allow genetic regulation through light control.

Therefore we are working on cloning strategies that would allow us to fuse natural "wild" light-sensitive domains with regulatory proteins. The idea is to allow transmission of the conformational change induced by light (on the light-sensitive domain) to the DNA-binding domain. This transmitted conformational change would then result in an increase or decrease of the regulatory domain's affinity for the DNA promoter site.

The overal effect would thus be a genetic expression controlled by light!

Where we are from

We are all studying at EPFL aka the Swiss Institute of Technology of Lausanne. The campus is located near the shore of lake Geneva in the surroundings of the city of Lausanne, 50 km away from Geneva.

@@ Line 43: / Line 43: @@
-== '''Where we are from''' ==
-We are all studying at EPFL aka ''the Swiss Institute of Technology of Lausanne''. The campus is located near the shore of lake Geneva in the surroundings of the city of Lausanne, 50 km away from Geneva.
+== '''What we want to do''' ==
+Light-sensitive proteins can easily be found in nature.
-[[Image: EPFL_LOG_RVB-55.jpeg|200px|center|EPFL]]
+In this project, our aim is to design a fusion/hybrid protein that would allow genetic regulation through light control.
+Therefore we are working on cloning strategies that would allow us to fuse natural "wild" light-sensitive domains with regulatory proteins. The idea is to allow transmission of the conformational change induced by light (on the light-sensitive domain) to the DNA-binding domain. This transmitted conformational change would then result in an increase or decrease of the regulatory domain's affinity for the DNA promoter site.
+The overal effect would thus be a genetic expression controlled by light!
-== '''What we want to do''' ==
-Light-sensitive proteins can easily be found in nature.
-In this project, our aim is to design a fusion/hybrid protein that would allow genetic regulation through light control.
-Therefore we are working on cloning strategies that would allow us to fuse natural "wild" light-sensitive domains with regulatory proteins. The idea is to allow transmission of the conformational change induced by light (on the light-sensitive domain) to the DNA-binding domain. This transmitted conformational change would then result in an increase or decrease of the regulatory domain's affinity for the DNA promoter site.
+== '''Where we are from''' ==
+We are all studying at EPFL aka ''the Swiss Institute of Technology of Lausanne''. The campus is located near the shore of lake Geneva in the surroundings of the city of Lausanne, 50 km away from Geneva.
+[[Image: EPFL_LOG_RVB-55.jpeg|200px|center|EPFL]]
-The overal effect would thus be a genetic expression controlled by light!