Conditioned Reflex Mimicking in E.coli
We are engineering our E.coli cells to process the correlation information of two environmental signal, similar to the process of classical conditioning in higher organisms. In our circuits we use a bistable switch as the memory module to represent the memory state; we also constructed a series of AND gates which can sense conditioned and unconditioned signals, and output a repressor protein to change the memory state of the bistable switch. In this way, our E.coli cells can convert the information on the concurrence of two signals to its memory. After the memory module is switched, given the conditioned stimulus, E.coli will activate its reporter module and thus exhibit the "conditioned response".
 Logic Circuit of the System
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Peking University
Peking University is a comprehensive and national key university. The campus, known as "Yan Yuan"(the garden of Yan), is situated at Haidian District in the western suburb of Beijing, with a total area of 2,743,532 square metres (or 274 hectares). It stands near to the Yuanmingyuan Garden and the Summer Palace.
Peking University is proud of its outstanding faculty, including 53 members of the Chinese Academy of Sciences (CAS), 7 members of the Chinese Academy of Engineering (CAE), and 14 members of the Third World Academy of Sciences (TWAS).
The university has effectively combined research on important scientific subjects with the training of personnel with a high level of specialized knowledge and professional skill as demanded by the country's socialist modernization. It strives not only for improvements in teaching and research work, but also for the promotion of interaction and mutual promotion among various disciplines.
Thus Peking University has become a center for teaching and research and a university of a new type, embracing diverse branches of learning such as basic and applied sciences, social sciences and the humanities, and sciences of medicine, management, and education. Its aim is to rank among the world's best universities in the future.
Acknowledgement
The PKU iGEM2009 Team strongly acknowledges following institutes/companies
We also want to thank the following Professors of the Life Science School, for supporting us with equipments and reagents.
[http://www.bio.pku.edu.cn/faculty/chenjg/ Prof. Jianguo Chen]
[http://www.bio.pku.edu.cn/faculty/liud/ Prof. Dong Liu]
[http://www.bio.pku.edu.cn/faculty/wangsq/ Prof. Shiqiang Wang]
[http://www.bio.pku.edu.cn/faculty/wangyp/ Prof. Yiping Wang]
[http://www.bio.pku.edu.cn/faculty/yulc/ Prof. Longchuan Yu]
[http://www.bio.pku.edu.cn/faculty/zhangy/ Prof. Yan Zhang]
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