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Overview Sensitivity Tuner --- Characterisation --- Modelling Colour Generators --- Carotenoids (Orange/Red) --- Melanin (Brown) --- Violacein (Purple/Green) The Future Safety

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Overview

Previous iGEM teams have focused on genetically engineering bacteria to respond to novel inputs, especially biologically significant compounds to engineer bacterial biosensors. There is an unmistakable need to also develop devices that can 1) manipulate the input by changing the behavior of the response of the input-sensitive promoter, and that can 2) report using clear, user-friendly outputs. The most popular output is the expression of a fluorescent protein, detectable using fluorescence microscopy. But, what if we could simply see the output with our own eyes?

The Cambridge 2009 iGEM team is engineering E. coli to produce different pigments in response to different concentrations of an inducer. Thus, we are developing bacterial "colour output machines."