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Ethics

Ethics is an important issue to think about, especially when we are considering working with toxic materials and modifying a life form.

iGEM-UK meeting — 24 June 2009

Ethical, Legal, Social Aspects of Synthetic Biology — Brainstorming exercise

What can engineering bring to biology?

• Further understanding of systems that are not understood
• Make useful organisms (e.g. electricity) [?]
• Make standards (+tick)
• Prediction/verification tools (+tick)
• Make biology more powerful, maybe uncontrollable
• Feedback – design & modelling
• Maths
• Callout charges. Help desks. Linux.
• Predictable outcomes
• Unrealistic expectations (+tick)
• A creative process
• Objective overview of the system
• Optimization
• The design process
• Problems/misunderstandings
• Mindset focusing on solving problems instead of gaining knowledge
• Solutions ☺
• Complex designs
• Innovation
• Mass production
• Bioart

What features of biology could be exploited by synthetic biology ? • Adapts • Replication • Species homology • Communication • Exploits standard parts within and between species ? • Can create a feature in a bug by using/mixing parts from other species • Synthetic organisms (e.g. plants) might outcompete wildtype ones • Exponential growth • System regulation • Self-preservation instinct • Mini-elephants & purple kittens • Molecular recognition • Self-assembly • Parallel processing • Evolution • Precise (molecular) control systems • Dinosaurs • Targeted solutions (e.g. to solve growing antibiotic resistance) • Stochasticity • Natural instinct to live • Neuroscience principles (e.g. neural networks) • Harnessing biological reactions that chemistry cannot yet accomplish

What kinds of applications could you imagine for synthetic biology in 50 years’ time? • Medical: o Vaccines o Transplantation /stem cells / making organs o Pushing human physical/mental abilities to new levels o Release of drugs by bacteria / enzymes by failed organs? o Destruction of malignant cells • No more ageing of humans. Eternal life? • A cure for flatulence • Personal activatable fluorescence • Biocomputing [linked to] • [linked with] living systems • Oxygen producing bugs • Outer space colonization [linked to] • [linked with] air recyclers + waste recyclers • Terraforming [with comment ‘Yes! ☺’] • Biofuels + biofuel cells • Biocomputers • Bio-diagnosers • Pets with logos • Superbugs! • Improved desalinisation • Houses grown from seeds • Artificial immune system • ‘super’ humans with more abilities? • Art • Food production • Anti-ageing. Anti-wrinkle. No more botox • Sleep button on kids • Remote control wake-up button for students • Military applications? (with funny face :|) • Dinosaurs! • Synthetic biology diseases [?]

What broader social challenges or questions face the synthetic biology community? • Public understanding of biology [annotated to include ‘misconceptions’] [with arrow drawn to] • [with arrow from] Commercial awareness of synthetic biology applications • Religion (sanctity of life) • Copyright (intellectual property) • Safety (products and methods) • Unethical use of technology (like any other technology) • Changing habits • Eventual creation of a sentient being? • Press! • Funding • Politics • X-Men Homo betterthanus • Acceptable range of colours for kittens/dinosaurs • Acceptability of creating new life forms which must be destroyed at the end of the experiment • Alteration of ecosystems • Non-compatible biologies (e.g. not DNA-based)

What legal and regulatory issues face synthetic biology? • Patents. Ensuring that BioBrick parts are free to the public • Creative commons law • Health & safety • DIY biology. Genetic transformations at home (crazy face!!!!!) • Bioterrorism Act/legislation • Synthetic biology affecting medicine • Coordination between countries • Establishment of trust in biological products o Biological certificates o Proper education programs ☺ • Selection of model organisms • Eventual use in humans ☺ • What are the limits? Are there any limits? • Synthetic biology black market • Differing laws between countries • Absence of applicable laws in some (eg. 3rd world/nations.) • Legal status of synthetic organisms • Government legislation – misconceptions of synthetic biology and how we would use it

What ethical questions are raised by synthetic biology? • Is synthetic life still life? • What is life? • Do synthetic organisms have rights? • Should you patent synthetic life? • Is it ok to make a synthetic species extinct? • How synthetic is synthetic? • Who is responsible? • Who has the right to benefit from the advantages of synthetic organisms? • Are we prepared to take responsibility? • Should synthetic organisms be introduced into human physiological systems? • What organisms are we allowed to synthesize? • Are we ready to be replaced by synthetical forms of lives? (synthetical humans) • Are they actually alive? • Are you ready to treat them the same way as ‘naturals’? • Who can and cannot work in synthetic biology? • Can you stop them once created? No switch! • Are we trying to play ‘God’? • Is it right to have lab strains? • Is it ok to create synthetic weapons?

Please write down one word to describe how you feel about synthetic biology (please do this individually; duplications allowed) • Complicated • Zeitgeist • Object oriented Gen. Eng. • The science of 21st century • Awesome • Promise • Fun and creativity • Worthy