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Team:EPF-Lausanne/Team
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Light-sensitive proteins can easily be found in nature. | Light-sensitive proteins can easily be found in nature. | ||
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Our aim is to design a fusion/hybride protein that would allow genetic regulation through light control. | Our aim is to design a fusion/hybride protein that would allow genetic regulation through light control. | ||
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Therefore we are working on cloning strategies that would allow us to fuse natural "wild" light-sensitive domains with regulatory proteins. The idea is to allow transmission of the conformational change induced by light (on the light-sensitive domain) to the DNA-binding domain. This transmitted conformational change would then result in an increase or decrease of the regularotry domain's affinity for the DNA promoter site. | Therefore we are working on cloning strategies that would allow us to fuse natural "wild" light-sensitive domains with regulatory proteins. The idea is to allow transmission of the conformational change induced by light (on the light-sensitive domain) to the DNA-binding domain. This transmitted conformational change would then result in an increase or decrease of the regularotry domain's affinity for the DNA promoter site. | ||
Revision as of 22:04, 9 July 2009
Who we are
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We are a team of undergraduates with an interdisiplinary background. Most of us are from the life sciences faculty but some of us are from microengineering, mechanical engineering and chemistry.
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Where we're from
We are all studying at EPFL aka the Swiss Institute of Technology. The campus is located near the shore of lake Geneva in the surroundings of the city of Lausanne, 50 km away for Geneva.
What we want to do
Light-sensitive proteins can easily be found in nature.
Our aim is to design a fusion/hybride protein that would allow genetic regulation through light control.
Therefore we are working on cloning strategies that would allow us to fuse natural "wild" light-sensitive domains with regulatory proteins. The idea is to allow transmission of the conformational change induced by light (on the light-sensitive domain) to the DNA-binding domain. This transmitted conformational change would then result in an increase or decrease of the regularotry domain's affinity for the DNA promoter site.
The overall effect would be a genetic expression control by light!
