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Team:Imperial College London/Project Overview
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The inspiration behind <b><i>The E.ncapsulator</i></b> was the inherent difficulty in delivering protein pharmaceuticals to the gut. Due to the delicate nature of proteins and the highly acidic environment present in the stomach, protein molecules are readily broken down - making oral drug delivery of protein pharmaceuticals impossible.<br> | The inspiration behind <b><i>The E.ncapsulator</i></b> was the inherent difficulty in delivering protein pharmaceuticals to the gut. Due to the delicate nature of proteins and the highly acidic environment present in the stomach, protein molecules are readily broken down - making oral drug delivery of protein pharmaceuticals impossible.<br> | ||
[[Image:II09_Theproblem2.png|400px|center]] | [[Image:II09_Theproblem2.png|400px|center]] | ||
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| + | Prevalance of Phenylketonuria: 1 per 10,000 - 15,000 newborns are diagnosed with phenylketonuria in the US, Genetics Home Reference website | ||
| + | Prevalance Rate: approx 1 in 10,000 or 0.01% or 27,200 people in USA [about data] | ||
| + | Incidence (annual) of Phenylketonuria: 1 of every 10,000 infants in the United States (NIDCD) | ||
| + | Incidence Rate: approx 1 in 10,000 or 0.01% or 27,200 people in USA [about data] | ||
| + | Incidence extrapolations for USA for Phenylketonuria: 27,199 per year, 2,266 per month, 523 per week, 74 per day, 3 per hour, 0 per minute, 0 per second. Note: this extrapolation calculation uses the incidence statistic: 1 of every 10,000 infants in the United States (NIDCD) | ||
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| + | http://www.wrongdiagnosis.com/p/phenylketonuria/stats.htm | ||
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| + | 17,000,000 U.S. adults have physician-diagnosed diabetes (about 7.5 million males and 9.5 million females). | ||
| + | 1,600,000 new cases of diagnosed diabetes are diagnosed every year. | ||
| + | 2005 death rates were 26.5 per 100,000 white males, 50.8 per 100,000 black males; 19.3 per 100,000 white females and 43.8 per 100,000 black females. | ||
| + | 584,000 people diagnosed with diabetes mellitus were discharged from U.S. hospitals in 2006. Of these, 283,000 were males and 301,000 were females. | ||
| + | At least 65 percent of people with diabetes mellitus die of some form of heart disease or stroke. | ||
| + | The age-adjusted (2000 standard) prevalence of physician-diagnosed diabetes in adults age 20 and older is (NHANES [2003–06], NCHS/NHLBI)... | ||
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| + | For non-Hispanic whites, 5.8 percent of men and 6.1 percent of women. | ||
| + | For non-Hispanic blacks, 14.9 percent of men and 13.1 percent of women. | ||
| + | For Mexican Americans, 11.3 percent of men and 14.2 percent of women. | ||
| + | The percentage of adults age 18 and older who have been told they have diabetes is 17.2 percent of American Indians/Alaska Natives; 8.9 percent of Asians and 11.1 percent of Hispanics or Latinos (NHIS [2007], NCHS). | ||
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| + | http://www.americanheart.org/presenter.jhtml?identifier=4551 | ||
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=Project Overview= | =Project Overview= | ||
Revision as of 16:58, 18 October 2009
Contents |
Motivation
The inspiration behind The E.ncapsulator was the inherent difficulty in delivering protein pharmaceuticals to the gut. Due to the delicate nature of proteins and the highly acidic environment present in the stomach, protein molecules are readily broken down - making oral drug delivery of protein pharmaceuticals impossible.
Project Overview
The E.ncapsulator is a novel protein manufacture and delivery platform designed to overcome these difficulties. In order to learn more about each module of the system and what its doing, hover over the different parts of the image below:
Major Results
Achievements
