Synthetic Transcriptional Cascade

Transcriptional cascades can be seen as temporal programs of successive gene expression (4). This gene configurations (or circuits) have the capability to integrate signals and trigger events after a delay from the initial detection event. As described before, such characteristic is needed in our project; therefore we considered two approaches based on transcriptional cascades. After some preliminary analysis, the approach termed negative synthetic transcriptional cascade was chosen to be developed.

• Preliminary approaches

• Synthetic Transcriptional Cascade: The plan

• Results

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