Team:EPF-Lausanne/Modeling

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Revision as of 08:55, 30 July 2009



Contents

                               

Modeling




To do

- Model allosteric interactions between LOVTAP & TrpR
What will be done:
- Model of LOVTAP in dark phase
- Model of LOVTAP in light phase
- Characterize how the J-alpha helix changes
- Model structural changes that enhance the switch feature of LOVTAP e.g. in dark phase: really weak interaction between LOVTAP and the corresponding DNA sequence, in light phase: strong binding of LOVTAP on DNA.
- Between Light state and Dark State
- RMS between light state and dark state
- length between the two arms N C
- only cytochrome with interactions in light state and dark state


To envisage


- Molecular mutational assay



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