Team:IBB Pune/Modeling

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<html><p><span style="font-weight:bold; font-size:200%; color:#F07211;">Project 1- A Model Of The Snowdrift Game</span></p></html>
<html><p><span style="font-weight:bold; font-size:200%; color:#F07211;">Project 1- A Model Of The Snowdrift Game</span></p></html>
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This is a Model of the Snowdrift game
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This model assumes use of two different strains as co-operators and defectors.
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Co-operators constitutively secrete/produce b-gal. Defectors cannot secrete/produce B-gal.
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This model is for a Single iteration of the experiment. i.e. the culture is initiated in shaker flask and allowed to grow.
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In order to find ESS or stable equilibria, we will have to repeatedly subculture the cells under similar conditions, by replacing the medium or supplying fresh medium. In such a setup, the input for the next cycle of expts will be the output of the previous cycle of expts.
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===Assumptions===
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At time t=0;
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There are 'k' co-operators and 'N-k' defectors
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Medium contains 'L' mg/ml of lactose, glucose conc. (g) = 0
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Culture is well mixed.
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Extracellular Enzyme conc (Ec) = 0 units/ml
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Artificial assumptions
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<p>Glucose is consumed by all cells. Galactose is also consumed at the same rate  Gc mg/cell/min/ml.
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The metabolic benefit due to glucose and galactose is same.So effectively each lactose molecule gives rise to 2 glucose molecules</p>
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<p>There is no intracellular lactose metabolism (only extracellular). </p>
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<p>There is no lag in enzyme production and secretion.</p>
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<p>Rate of degradation of enzyme is zero</p>

Revision as of 06:25, 21 October 2009




Modelling




Project 1- A Model Of The Snowdrift Game


This is a Model of the Snowdrift game This model assumes use of two different strains as co-operators and defectors. Co-operators constitutively secrete/produce b-gal. Defectors cannot secrete/produce B-gal.

This model is for a Single iteration of the experiment. i.e. the culture is initiated in shaker flask and allowed to grow.

In order to find ESS or stable equilibria, we will have to repeatedly subculture the cells under similar conditions, by replacing the medium or supplying fresh medium. In such a setup, the input for the next cycle of expts will be the output of the previous cycle of expts.

Assumptions

At time t=0;

There are 'k' co-operators and 'N-k' defectors

Medium contains 'L' mg/ml of lactose, glucose conc. (g) = 0

Culture is well mixed.

Extracellular Enzyme conc (Ec) = 0 units/ml

Artificial assumptions

Glucose is consumed by all cells. Galactose is also consumed at the same rate Gc mg/cell/min/ml. The metabolic benefit due to glucose and galactose is same.So effectively each lactose molecule gives rise to 2 glucose molecules

There is no intracellular lactose metabolism (only extracellular).

There is no lag in enzyme production and secretion.

Rate of degradation of enzyme is zero

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