Team:PKU Beijing/Modeling/Result

From 2009.igem.org

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*'''The Result Should Fit A Dog's Reaction'''
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OK, what we do this year is to simulate Pavlov's dog. Thus, our modeling should not only concentrate on biological mechanism, but also follow a dog's reaction towards certain things. Here're some circumstance we've thought up. If you have new ideas, feel free to email us! Please email to c.z.tian AT gmail.com
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'''GFP output should be stronger under a food stimulus'''<br>
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Food is a direct stimulus while bell is a more indirect one. Generally, under direct stimulus, the dog will react stronger.
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'''If the dog has memory and is given a bell stimulus, GFP output should have a delay'''<br>
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The dog takes time to link BELL with FOOD :]
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*'''The Value for Each Parameter Should NOT Be Too Extreme'''
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This is also an attemp to simulate the system as accurately as possible.
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Now, let's see the result!
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==='''Result - T3 RNA Polymerase'''===
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==='''Result - P2'''===
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Revision as of 19:41, 17 October 2009

 
Modeling > Result

After ODE and Parameters, it's time to see the simulation result.

The Goal of Simulation

Of course, the ultimate goal of modeling is to simulate the circuit as accurate as possible. However, due to the complexity of biological system and very little we have known about it, it's almost impossible to simulate exactly. Thus, we come up a series of standards, which will be the main goals of our modeling. Here're the standards:

  • The Biological System Should Follow the Truth Table

As we mentioned in project section, the dog (and of course the model) should react in a specific way under certain circumstances, which has been concluded into a truth table. To simulate perfectly, our model should follow the truth table, which is the primary goal without doubt.

Truth Table
NO MEMORY WITH MEMORY
FOOD BELL GFP FOOD BELL GFP
0 0 0 0 0 0
1 0 1 1 0 1
0 1 0 0 1 1
1 1 1 1 1 1
  • The Result Should Fit A Dog's Reaction

OK, what we do this year is to simulate Pavlov's dog. Thus, our modeling should not only concentrate on biological mechanism, but also follow a dog's reaction towards certain things. Here're some circumstance we've thought up. If you have new ideas, feel free to email us! Please email to c.z.tian AT gmail.com

GFP output should be stronger under a food stimulus
Food is a direct stimulus while bell is a more indirect one. Generally, under direct stimulus, the dog will react stronger.

If the dog has memory and is given a bell stimulus, GFP output should have a delay
The dog takes time to link BELL with FOOD :]

  • The Value for Each Parameter Should NOT Be Too Extreme

This is also an attemp to simulate the system as accurately as possible.

Now, let's see the result!

Result - T3 RNA Polymerase

Result - P2



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