Team:Paris/Collaborations

From 2009.igem.org

(Difference between revisions)
(Modeling collaborations)
(Modeling collaborations)
Line 18: Line 18:
for k = 1:6
for k = 1:6
      
      
-
    H = k;
+
H = k;
-
    t0 = 0 ;
+
 
-
    tf = 10 ;
+
t0 = 0 ;
-
    x0 = [0 ; 0 ; 4000 ; 0];
+
 
-
    [t, x] = ode23(@delaydevice, [t0:0.1:tf],x0,[],H);
+
tf = 10 ;
-
    subplot(3,2,k)
+
 
-
    plot (t,x)
+
x0 = [0 ; 0 ; 4000 ; 0];
 +
 
 +
[t, x] = ode23(@delaydevice, [t0:0.1:tf],x0,[],H);
 +
 
 +
subplot(3,2,k)
 +
 
 +
plot (t,x)
 +
 
end  
end  
 +
legend({'prot','lacI','TetR','TolRII'});
legend({'prot','lacI','TetR','TolRII'});
Line 34: Line 42:
function xd = delaydevice(t, x, H)
function xd = delaydevice(t, x, H)
 +
%Resolution of a differential system
%Resolution of a differential system
% Dilution of proteins
% Dilution of proteins
 +
gamma = 1;
gamma = 1;
 +
gammaLVA = 3;
gammaLVA = 3;
 +
 +
% pBad Activation
% pBad Activation
 +
Ara = 10000;
Ara = 10000;
 +
beta1 = 4000;
beta1 = 4000;
 +
beta2 = 4000;
beta2 = 4000;
 +
K1 = 40;
K1 = 40;
 +
K2 = 40;
K2 = 40;
 +
% pLac Repression
% pLac Repression
 +
beta3 = 2000;
beta3 = 2000;
 +
K3 = 40;
K3 = 40;
% pTet Repression
% pTet Repression
 +
beta4 = 2000;
beta4 = 2000;
 +
K4 = 40;
K4 = 40;
 +
xd = zeros(size(x));
xd = zeros(size(x));
 +
xd(1) = -gamma*x(1)+ beta1*(Ara/K1)/(1+(Ara/K1)); %Protein creation
xd(1) = -gamma*x(1)+ beta1*(Ara/K1)/(1+(Ara/K1)); %Protein creation
 +
xd(2) = -gammaLVA*x(2)+ beta2*(Ara/K2)/(1+(Ara/K2)); % lacI creation
xd(2) = -gammaLVA*x(2)+ beta2*(Ara/K2)/(1+(Ara/K2)); % lacI creation
 +
xd(3) = -gamma*x(3)+ beta3*(K3/(K3+(x(2))^2)); % TetR creation
xd(3) = -gamma*x(3)+ beta3*(K3/(K3+(x(2))^2)); % TetR creation
 +
xd(4) = -gamma*x(4)+ beta4*(K4/(K4+x(3))); % TolRII creation
xd(4) = -gamma*x(4)+ beta4*(K4/(K4+x(3))); % TolRII creation
 +
end
end
 +
 +
end
end

Revision as of 03:40, 22 October 2009

iGEM > Paris > Home > Collaborations

Modeling collaborations

As it happened that we share with the BCCS-Bristol projet some similarities and especially on the modeling part we have decided to contact them in order to either find synergies or just to be sure not to make a redondant modeling work. Obviously it seems that we were not working on the same domain.

So in order to make a complete modelisation of the "project" we provided them unconditionally with the Mathlab source code of the production of vesicles.


Here you can find the Matlab code, with respect to the iGEM Open Source concept :
function Delay_Device_Simple>

close all

for k = 1:6

H = k;

t0 = 0 ;

tf = 10 ;

x0 = [0 ; 0 ; 4000 ; 0];

[t, x] = ode23(@delaydevice, [t0:0.1:tf],x0,[],H);

subplot(3,2,k)

plot (t,x)

end

legend({'prot','lacI','TetR','TolRII'});

function solver(k)

end


function xd = delaydevice(t, x, H)

%Resolution of a differential system


% Dilution of proteins

gamma = 1;

gammaLVA = 3;


% pBad Activation

Ara = 10000;

beta1 = 4000;

beta2 = 4000;

K1 = 40;

K2 = 40;


% pLac Repression

beta3 = 2000;

K3 = 40;

% pTet Repression

beta4 = 2000;

K4 = 40;



xd = zeros(size(x));


xd(1) = -gamma*x(1)+ beta1*(Ara/K1)/(1+(Ara/K1)); %Protein creation

xd(2) = -gammaLVA*x(2)+ beta2*(Ara/K2)/(1+(Ara/K2)); % lacI creation

xd(3) = -gamma*x(3)+ beta3*(K3/(K3+(x(2))^2)); % TetR creation

xd(4) = -gamma*x(4)+ beta4*(K4/(K4+x(3))); % TolRII creation

end


end


Ethic collaborations

We wanted to support the debates around ethics in science, in fact we also developped several points with our specialist in epistemology.


Therefore answering the Valencia poll was the opportunity to widen our range of questions about biosciences, to share knowledge, and to prove that we feel concerned by the problem that ethics tackles.


All the team answered the poll and we are grateful to Valencia for rewarding us with a gold medal ^^

Software tool collaborations

In order to develop a fully operational tool we created a poll that we send to other igem team to ask if it could be a great help for them or not and if they have also advices and expectations concerning this software.


2 Teams answered :


We had some interactions with the Freiburg_software team, specially with Paul Staab. They have developed a synthetic biological software suite, based on Google's collaboration and communication tool Wave : SynBiowave. The actual version is 0.2 but it is a project with a great potential!


Open book.gif

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