Team:Paris/Transduction modeling Deterministic and Stochastic Simulations

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Modeling

• Introduction
• A. The Fec Operon as used in our system : chemical equations and kinetics
• B. Deterministic and Stochastic Simulations
• C. Results and discussion

Deterministic and Stochastic Simulations

To study our model, we decided to run two type of simulations. First of all, we have started with deterministic simulation in order to see whether our description of the chemical cascade reflected our understanding and expected behaviour of the reception system. Then, to check whether our system was sensible to molecular noise, we decided to run exact stochastic simulations based on the Gillespie method.

Deterministic Model

ff

Stochastic Simulations

Several runs of stochastic simulations were run for the different values of k and the different initial amounts of FecA. We used a Gillespie algorithm to compute the amounts of molecules at each step  ; the simulations were run with Matlab Simbiology toolbox.