Team:Paris/Transduction overview

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===Introduction===
===Introduction===
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This part of the project was focus on two points:
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fusion between the vesicle and the targeted bacteria.
- to enable gene transcription after fusionning OMVs with the outer membrane of the receiving bacterium.  
- to enable gene transcription after fusionning OMVs with the outer membrane of the receiving bacterium.  

Revision as of 16:36, 3 September 2009

iGEM > Paris > Reception > Overview

Overview

Introduction

This part of the project was focus on two points:

fusion between the vesicle and the targeted bacteria.

- to enable gene transcription after fusionning OMVs with the outer membrane of the receiving bacterium.


We also hope that we could achieve this aim without sacrifying important proprieties of our message : specific, repeatable , multidirectional. It seems that we have two possible ways : the ABC transporters or the two component systems . ABC transporters and two component systems are natural transport system (export or import) of information, nutriments or toxines.


There is another possibility but the mecanism is mostly unknown : the DNA-containing OMVs which could be a useful mean of information transport.

References

  1. 1 D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. Lopilato JE & Beckwith JR. 1984 - [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=6327616 6327616]
  2. 2 Signal transfer through three compartments: transcription initiation of the Escherichia coli ferric citrate transport system from the cell surface. Härle C & Braun V. 1995 - [http://www.ncbi.nlm.nih.gov/pubmed/7729419 7729419]
  3. 3 A comparative analysis of ABC transporters in complete microbial genomes. Tomii K & Kanehisa M. 1998- [http://www.ncbi.nlm.nih.gov/pubmed/9799792 9799792]
  4. 4 The CpxRA signal transduction system of Escherichia coli: growth-related autoactivation and control of unanticipated target operons.De Wulf P & Lin EC. 1999 - [http://www.ncbi.nlm.nih.gov/pubmed/10542180 10542180]
  5. 5 Two-component signal transduction. Stock AM & Goudreau PN. 2000- [http://www.ncbi.nlm.nih.gov/pubmed/10966457 10966457]
  6. 6 Vesicle-mediated transfer of virulence genes from Escherichia coli O157:H7 to other enteric bacteria. Yaron S & Matthews KR. 2000- [http://www.ncbi.nlm.nih.gov/pubmed/11010892 11010892]
  7. 7 Periplasmic binding proteins: a versatile superfamily for protein engineering. Dwyer MA & Hellinga HW. 2004- [http://www.ncbi.nlm.nih.gov/pubmed/11010892 11010892]
  8. 8 Gene regulation by transmembrane signaling. Braun V & Sauter A. 2006- [http://www.ncbi.nlm.nih.gov/pubmed/16718597 16718597]
  9. 9 Signal transduction: networks and integrated circuits in bacterial cognition. Baker MD & Stock JB 2007- [http://www.ncbi.nlm.nih.gov/pubmed/18054766 18054766]
  10. 10 Systems biology of bacterial chemotaxis. Baker MD & Stock JB. 2007- [http://www.ncbi.nlm.nih.gov/pubmed/16529985 16529985]
  11. 11 Control of the transcription of a short gene encoding a cyclic peptide in Streptococcus thermophilus: a new quorum-sensing system? Ibrahim M & Monnet V. 2007- [http://www.ncbi.nlm.nih.gov/pubmed/17921293 17921293]
  12. 12 SRP and Sec pathway leader peptides for antibody phage display and antibody fragment production in E. coli. Thie H & Hust M. 2008- [http://www.ncbi.nlm.nih.gov/pubmed/18504019 18504019]
  13. 13 Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm. Kyriakidis DA & Tiligada E. 2009- [http://www.ncbi.nlm.nih.gov/pubmed/19198978 19198978]
  14. 14 comparative analysis of ABC transporter. Tomii & Kanehisa 2009- [http://genome.cshlp.org/content/8/10/1048.full.html#ref-list-1 pdf-link]


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