Team:Paris/Transduction overview

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Overview

• Introduction
• A. Fusion
  • A.1 jun/fos
  • A.2 G3P
  • A.3 Snares
• B. Transduction
  • B.1 ABC transporters
  • B.2 Two Component System
• C. Our strategy
• D. Construction

Introduction

- to enable gene transcription after fusionning OMVs with the outer membrane of the receiving bacterium.

We also hope that we could achieve this aim without sacrifying important proprieties of our message : specific, repeatable , multidirectional. It seems that we have two possible ways : the ABC transporters or the two component systems . ABC transporters and two component systems are natural transport system (export or import) of information, nutriments or toxines.

There is another possibility but the mecanism is mostly unknown : the DNA-containing OMVs which could be a useful mean of information transport.

References

1. ^ - 179564
2. ^The Tol-Pal proteins of the Escherichia coli cell envelope an energized system required for outer membrane integrity. Lloubès & Journet 2001 - 11501670
3. ^Improved methods for producing outer membrane vesicles in gram-negative bacteria. Henry & Lloubès 2004 - 15249060

1. 1995- Cosima Harle & Volkmar Braun - Signal transfer through three compartments transcription initiation of the Escherichia coiferric citrate transport system from the cell surface
2. 2000 - Stock & Goudreau – Two-component signal transduction
3. 2001 - Mishima & Murata - Super-channel in bacteria function and structure of the macromolecule import system mediated by a pit-dependent ABC transporter
4. 2009 - Akyriakidis & Tiligada – signal transduction TCS the AtoSC paradigm
5. 2009 - Tomii & Kanehisa – comparative analysis of ABC transporter